Henry is a precocious young boy, conceived in a petri-dish, raised by his single mother, Patricia, and is smarter than all of his peers. However, the one question he can't answer is, who is his father? Henry's attempts at locating his father lead him to Dr. Slavkin O'Hara, a university professor who has decided to raise his daughter, Audrey, as a psychology experiment in a world free of gender bias. Patricia starts fearing that she's losing her son, Audrey wishes she didn't have a father, Dr. O'Hara has no idea how to keep his daughter happy, and Henry may just have found the family he was looking for.

Ojo and Unc Nunkie are out of food, so they decide to journey to the Emerald City where they will never starve. Along the way, they meet Mewel, a waif and stray (mule) who leads them to Dr. Pipt, who has been stirring the powder of life for nine years. Ojo adds plenty of brains to Margolotte's Patchwork servant before she is brought to life with the powder. When Scraps does come to life, she accidentally knocks the liquid of petrifaction upon Unc Nunkie, Margolotte, and Danx (daughter Jesseva's boyfriend). So all go on separate journeys to find the ingredients to the antidote. (Of course Jesseva has Danx shrunken to take with her, which causes trouble with Jinjur.) Of course, no one ever told Ojo that some of the ingredients were illegal to obtain...

Rose is involved in a motorcycle accident, and has experimental surgery performed in order to save her life. However, she develops a taste for blood. Her victims grow in number as well as madness, turning the city into chaos.